Gly-Pro-Glu

SIGMA/G3923 - ≥98% (HPLC)

Synonym: GPE; Glycyl-prolyl-glutamic acid

CAS Number: 32302-76-4
Empirical Formula (Hill Notation): C₁₂H₁₉N₃O₆
Molecular Weight: 301.30
MDL Number: MFCD00144405
Linear Formula: C₁₂H₁₉N₃O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G3923-10MG	10 mg	$101.00 1/EA		Add To Favorites
45-G3923-50MG	50 mg	$420.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
InChI key	JJGBXTYGTKWGAT-YUMQZZPRSA-N
Quality Level	100
SMILES string	NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O
storage temp.	−20°C

Biochem/physiol Actions:	Gly-Pro-Glu (GPE) is a neuroactive peptide and prevents the binding of glutamate to N-methyl-D-aspartate (NMDA) receptor. It positively regulates the potassium-mediated release of acetylcholine from rat cortical slices. Thus, it is involved in the control of brain function. In vitro studies show that this peptide confers neuroprotection to CA1-2 hippocampal neurons against excitotoxic insult.
Biochem/physiol Actions:	Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1.
Biochem/physiol Actions:	Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1. Gly-Pro-Glu is neuroprotective after central administration in animal models of neurodegenerative processes, such as Huntington’s, Parkinson’s, Alzheimer’s diseases, and varies acute brain injury animal models. The neuroprotective activity is not related to its affinity to glutamate receptor. Findings indicate that GPE mimics insulin-like growth factor I effects on the somatostatin system through a mechanism independent of β-amyloid clearance that involves modulation of calcium and glycogen synthase kinase 3β signaling.
General description:	IGF1 (insulin-like growth factor 1) protein is cleaved into des-N-(1-3)-IGF-1 and an N-terminal Gly-Pro-Glu (GPE tripeptide). It is thought to be an outcome of specific neural processing.
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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