Glucose-6-phosphate Dehydrogenase from baker’s yeast (S. cerevisiae)
SIGMA/G4134 - Type IX, lyophilized powder, 200-400 units/mg protein (modified Warburg-Christian)
Synonym: G-6-P-DH; Zwischenferment
CAS Number: 9001-40-5
EC Number: 232-602-6
MDL Number: MFCD00081656
Product Type: Chemical
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| β-NADP and β-NADPH content | ≤10 mmol/mol |
| application(s) | agriculture |
| form | lyophilized powder |
| mol wt | 128 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | 200-400 units/mg protein (modified Warburg-Christian) |
| storage temp. | −20°C |
| type | Type IX |
| Application: | Glucose-6-phosphate dehydrogenase is used:• To test ketose reductase activity in developing maize endosperm. • For recycling microassay of β-NADP and β-NADPH. • To measure the intracellular levels of NADPH and total NADP. • To measure the nicotinamide adenine dinucleotide (NAD) kinase kinetic assay activity. |
| Biochem/physiol Actions: | Glucose-6-phosphate dehydrogenase catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconolacetone as the first step in the pentose phosphate pathway. |
| Biochem/physiol Actions: | Glucose-6-phosphate dehydrogenase catalyzes the rate-limiting step in the pentose phosphate pathway. Its function involves the conversion of glucose-6-phosphate to 6-phosphogluconolacetone while generating NADPH, which is essential for the regeneration of glutathione The glutathione system utilizes nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) to effectively eliminate excess hydrogen peroxide. Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in regulating cell growth and survival. Their levels are higher in cells undergoing normal and neoplastic growth. Increased glucose-6-phosphate dehydrogenase activity plays a pivotal role in preventing reactive oxygen species mediated cell death. Glucose-6-phosphate dehydrogenase is over expressed in several cancers whereas its activity is reduced in hyperglycemia. A deficiency in glucose-6-phosphate dehydrogenase causes hemolysis. |
| General description: | Research area: Cell Signaling Glucose-6-phosphate dehydrogenase (G6PD) is a key metabolic enzyme of the pentose phosphate pathway. In S. cerevisiae, it is encoded by the ZWF1 gene. G6PD exists as a tetramer in its active form. |
| Other Notes: | One unit will oxidize 1.0 μmole of |
| Packaging: | 100, 250, 500, 1000 units in glass bottle |
| Physical form: | Lyophilized powder essentially sulfate-free, containing approx. 20% sodium citrate |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261 - P284 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: 200-400 units/mg protein (modified Warburg-Christian) |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 1.1.1.49 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |