Gly-Arg-Gly-Asp-Ser

SIGMA/G4391 - ≥97% (HPLC)

CAS Number: 96426-21-0
Empirical Formula (Hill Notation): C₁₇H₃₀N₈O₉
Molecular Weight: 490.47
MDL Number: MFCD00076459
Linear Formula: C₁₇H₃₀N₈O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G4391-1MG	1 mg	$90.50 1/EA		Add To Favorites
45-G4391-5MG	5 mg	$300.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
composition	Peptide content, ≥60%
form	powder
InChI	1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25,32)(H,29,30)(H,33,34)(H4,19,20,21)/t8-,9-,10-/m0/s1
InChI key	RGNVSYKVCGAEHK-GUBZILKMSA-N
Quality Level	200
SMILES string	NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
storage temp.	−20°C
technique(s)	blocking: suitable
	cell culture \| mammalian: suitable

Amino Acid Sequence:	Gly-Arg-Gly-Asp-Ser
Application:	Gly-Arg-Gly-Asp-Ser has been used- • as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice • for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1⁺ progenitor cell differentiation into SMCs (smooth muscle cells) • as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin • for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus
Biochem/physiol Actions:	Antagonist of integrin function
Biochem/physiol Actions:	Gly-Arg-Gly-Asp-Ser inhibits metastasis in syngeneic mice or in mice lacking platelet function, when co-injected with B16-Fl0 melanoma cells.
General description:	Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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