Goserelin acetate

SIGMA/G4919 - ≥99% (HPLC), white, powder

Synonym: [D-Ser(tBu)⁶,Azagly¹⁰]-LHRH acetate salt

CAS Number: 145781-92-6
Empirical Formula (Hill Notation): C₅₉H₈₄N₁₈O₁₄
Molecular Weight: 1269.41
MDL Number: MFCD01747329
Linear Formula: C₅₉H₈₄N₁₈O₁₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G4919-5MG	5 mg	$306.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
color	white
form	powder
InChI	1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1
InChI key	IKDXDQDKCZPQSZ-JHYYTBFNSA-N
Quality Level	200
shipped in	dry ice
SMILES string	CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NNC(N)=O
solubility	H₂O: 20 mg/mL, clear, colorless
storage temp.	−20°C
UniProt accession no.	P55248
	P01148
	P07490
	P13562
	P30968
	P30969
	Q01776

Amino Acid Sequence:	Glp-His-Trp-Ser-Tyr-Ser(tBu)-Leu-Arg-Pro-azaGly-NH2
Biochem/physiol Actions:	Goserelin acetate peptide results in significant inhibition of gonadotropin release and suppresses steroidogenesis in ovaries and testis. Thus, it leads to a reduction of testosterone to castration levels and estrogen to postmenopausal levels. Therefore, this peptide is used for reducing testosterone levels in patients with locally advanced prostate cancer.
Biochem/physiol Actions:	Goserelin is a synthetic analog of LHRH (leutinizing hormone releasing hormone). Goserelin is a LHRH agonist It is used in prostate cancer and breast cancer therapies and also in the treatment of endometriosis.
General description:	Goserelin acetate is a synthetic decapaptide, which is a potent analog of LHRH (luteinizing hormone releasing hormone).
General description:	Goserelin is used to guard ovary during breast-cancer adjuvant chemotherapy.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201 - P280 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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