GGTI 298 trifluoroacetate salt hydrate

SIGMA/G5169 - ≥90% (HPLC), film

Synonym: N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate

CAS Number: 1217457-86-7 (anhydrous)
Empirical Formula (Hill Notation): C₂₇H₃₃N₃O₃S · C₂HF₃O₂ · xH₂O
Molecular Weight: 593.66 (anhydrous basis)
MDL Number: MFCD06409252
Linear Formula: C₂₇H₃₃N₃O₃S · C₂HF₃O₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G5169-.25MG	250 µg	$130.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
color	colorless
form	film
	lyophilized
impurities	<10% dimer
InChI	1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1
InChI key	WALKWJPZELDSKT-UFABNHQSSA-N
mp	99.5-100 °C
Quality Level	100
SMILES string	OC(=O)C(F)(F)F.COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2cccc3ccccc23
solubility	DMSO: >20 mg/mL
storage temp.	−20°C

Application:	GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor: • to study the anticancer effects of statins along with GGTI 298 • to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium • to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population
Biochem/physiol Actions:	GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
mp	99.5-100 °C
Storage Temp.	−20°C
UNSPSC	51111800

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