GW4064

SIGMA/G5172 - ≥97% (HPLC)

Synonym: 3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

CAS Number: 278779-30-9
Empirical Formula (Hill Notation): C₂₈H₂₂Cl₃NO₄
Molecular Weight: 542.84
MDL Number: MFCD09971006
Linear Formula: C₂₈H₂₂Cl₃NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G5172-5MG	5 mg	$166.00 1/EA	Add To Favorites
45-G5172-25MG	25 mg	$678.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white
form	powder
InChI	1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+
InChI key	BYTNEISLBIENSA-MDZDMXLPSA-N
Quality Level	100
SMILES string	CC(C)c1onc(c1COc2ccc(C=Cc3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl
solubility	DMSO: 10 mg/mL, clear
storage condition	desiccated
storage temp.	2-8°C

Application:	GW4064 has been used: • to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosis • to examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS) • to treat ileal explants
Biochem/physiol Actions:	GW4064 is a FXR agonist.
Biochem/physiol Actions:	GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H319 - H413
Precautionary statements	P273 - P301 + P312 + P330 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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