Glycine
SIGMA/G5417
Synonym: Aminoacetic acid; Aminoethanoic acid; Glycocoll
CAS Number: 56-40-6
Empirical Formula (Hill Notation): C2H5NO2
Molecular Weight: 75.07
EC Number: 200-272-2
MDL Number: MFCD00008131; MFCD00008131
Linear Formula: NH2CH2COOH
Product Type: Chemical
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ATR-IR Spectra for Aminoacetic acid.
| application(s) | pharmaceutical (small molecule) |
| assay | ≥98.5% |
| biological source | non-animal source |
| foreign activity | cytotoxicity, tested |
| form | crystalline powder |
| impurities | endotoxin, heavy metals, trace metals, residual solvents, tested |
| InChI | 1S/C2H5NO2/c3-1-2(4)5/h1, |
| InChI key | DHMQDGOQFOQNFH-UHFFFAOYSA |
| mp | 240 °C (dec.) (lit.) |
| pH | 5.9-6.4 |
| pKa (25 °C) | (1) 2.35, (2) 9.60 |
| 2.35 | |
| Quality Level | 400  |
| SMILES string | NCC(O)=O |
| solubility | H2O: 100 mg/mL |
| suitability | suitable for manufacturing use |
| technique(s) | cell culture | mammalian: suitable |
| UV absorption | λ: 260 nm Amax: ≤0.04 |
| λ: 260 nm Amax: -0.006 | |
| λ: 280 nm Amax: ≤0.04 | |
| λ: 280 nm Amax: -0.003 |
| Application: | Glycine is a non-essential amino acid. It is the simplest of the amino acids and plays various roles in biology. It is structurally unique among the biological amino acids in that it does not have an asymmetric center, and thus is not chiral. It is commonly used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. |
| Biochem/physiol Actions: | Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. |
| General description: | Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program. M-Clarity Program Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service. |
| General description: | To request the documentation for this product, please contact Customer Support and select ‘Product Documentation’. Please note that access to the documentation for this product requires a confidentiality disclosure agreement. |
| Legal Information: | SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | ≥98.5% |
| mp | 240 °C (dec.) (lit.) |
| UNSPSC | 12352209 |