Globulins Cohn fraction II, III from goat
SIGMA/G5640
Synonym: Vitamin D binding protein
CAS Number: 68476-36-8
EC Number: 270-678-2
MDL Number: MFCD00164084
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G5640-5G
| assay | 73-90% protein basis (biuret) |
| biological source | goat |
| composition | Protein, 73-90% biuret |
| form | lyophilized powder |
| Quality Level | 300  |
| solubility | H2O: soluble 25 mg/mL |
| storage temp. | 2-8°C |
| Application: | Globulins were used in Biotin/avidin formulations. |
| Biochem/physiol Actions: | Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease. |
| General description: | Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis. |
| Other Notes: | Primarily γ-globulins |
| Packaging: | 5 g in poly bottle |
| Physical form: | Lyophilized powder containing NaCl |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 73-90% protein basis (biuret) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |