GW1929 hydrate
SIGMA/G5668 - >98% (HPLC), solid
Synonym: N-
CAS Number: 1049740-86-4
Empirical Formula (Hill Notation): C30H29N3O4 · xH2O
Molecular Weight: 495.57 (anhydrous basis)
MDL Number: MFCD11045925
Linear Formula: C30H29N3O4 · xH2O
Product Type: Chemical
| assay | >98% (HPLC) |
| form | solid |
| InChI | 1S/C30H29N3O4.H2O/c1-33(2 |
| InChI key | XSITZVFUXCLFMK-YCBFMBTMSA |
| originator | GlaxoSmithKline |
| Quality Level | 100  |
| SMILES string | [H]O[H].CN(CCOc1ccc(C[C@H |
| solubility | DMSO: 20 mg/mL |
| Application: | GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand: • to study its effects on plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) expression involved in adipogenesis • to study its effects on complement component 3 (C3) gene expression in human hepatoma cells • to activate PPARγ in human breast cancer cells |
| Biochem/physiol Actions: | GW1929 is a high affinity agonist of PPAR-γ. |
| Biochem/physiol Actions: | GW1929 is a non-thiazolidinedione and is involved in cell growth inhibition and regulating gene expression. It exhibits neuroprotective effects against global cerebral ischemic-reperfusion injury by DNA fragmentation and minimizing the inflammation. GW1929 participates in the inhibition of α7 N-acetylcholine receptor expression and promoter activity. It also influences the early growth response-1 (Egr-1) protein expression. |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Legal Information: | Sold for research purposes only, pursuant to an agreement with GlaxoSmithKline |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >98% (HPLC) |
| UNSPSC | 12352200 |