Gly-Pro-Arg-Pro amide

SIGMA/G5779 - ≥97% (HPLC)

Synonym: GPRP amide; Glycine-Proline-Arginine-Proline amide; Glycyl-L-prolyl-L-arginyl-L-prolinamide

CAS Number: 126047-75-4
Empirical Formula (Hill Notation): C₁₈H₃₂N₈O₄
Molecular Weight: 424.50
MDL Number: MFCD00237962
Linear Formula: C₁₈H₃₂N₈O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G5779-5MG	5 mg	$144.00 1/EA	Add To Favorites
45-G5779-25MG	25 mg	$493.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
InChI	1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1
InChI key	SCCTZYGEMPQRCV-AVGNSLFASA-N
Quality Level	200
SMILES string	NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(N)=O
storage temp.	−20°C
UniProt accession no.	P02751
	P04937
	P11276

Amino Acid Sequence:	Gly-Pro-Arg-Pro-NH2
Application:	Gly-Pro-Arg-Pro amide has been used- • as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin • for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice • during preparation of human soluble fibrin, to block the polymerization of soluble fibrin
Biochem/physiol Actions:	Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).
General description:	Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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