Geranylgeranyl pyrophosphate ammonium salt

SIGMA/G6025 - solution, ≥95% (TLC), ~1 mg/mL in methanol: NH₄OH (7:3)

Synonym: GGPP; all trans-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate ammonium salt

CAS Number: 6699-20-3 (free acid)
Empirical Formula (Hill Notation): C₂₀H₃₆O₇P₂ · xNH₃
Molecular Weight: 450.44 (free acid basis)
MDL Number: MFCD00156114
Linear Formula: C₂₀H₃₆O₇P₂ · xNH₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G6025-1VL	1 vial	$168.00 1/EA	Add To Favorites
45-G6025-5VL	5 vials	$572.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (TLC)
concentration	~1 mg/mL in methanol: NH₄OH (7:3)
form	solution
InChI	1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
InChI key	OINNEUNVOZHBOX-QIRCYJPOSA-N
packaging	vial of 200 μg
Quality Level	200
SMILES string	CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O
storage temp.	−20°C

Application:	Geranylgeranyl pyrophosphate ammonium salt has been used: • in the preparation of 2.5X reaction buffer for Rab GGTase assay • to add to the culture to further drive Hmg2 degradation • as a substrate to carryout in vitro enzymatic assays for the characterization of the prenyltransferases • to reverse the action of lovastatin and also used to examine the potential role of GGPP in the study to assess the effects of exposing the melanoma cell lines in the angiogenesis model as a co-culture to lovastatin in vitro
Biochem/physiol Actions:	Geranylgeranyl pyrophosphate (GGPP) is a major enzyme that participates in the secondary metabolism of chloroplast. GGPP synthase plays a key role in the biosynthesis of terpenoid. Protein geranylgeranylation, mediated by geranylgeranyl pyrophosphate participates in the development of the ventricular chamber. It also serves as a stage-specific signal to modulate the formation of cardiac cytoarchitecture the time of mid-gestation.
Biochem/physiol Actions:	Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	1 vial in serum bottle
Packaging:	5 vials in serum bottle

Symbol	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225 - H301 + H311 + H331 - H370
Precautionary statements	P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	WGK 2
Flash Point(F)	51.8 °F - closed cup
Flash Point(C)	11 °C - closed cup

Purity	≥95% (TLC)
Storage Temp.	−20°C
UNSPSC	12352211

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