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GW3965 hydrochloride

SIGMA/G6295 - ≥98% (HPLC), powder

Synonym: 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

CAS Number: 405911-17-3
Empirical Formula (Hill Notation): C33H31F3ClNO3 · HCl
Molecular Weight: 618.51
MDL Number: MFCD08276920
Linear Formula: C33H31F3ClNO3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G6295-5MG 5 mg
 $227.00
1/EA		 Add To Favorites
45-G6295-25MG 25 mg
 $774.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H
InChI key NMPUWJFHNOUNQU-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string Cl[H].OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c3ccccc3)Cc4cccc(c4Cl)C(F)(F)F)c1
solubility DMSO: ≥20 mg/mL
storage condition desiccated
Biochem/physiol Actions: GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively.
Biochem/physiol Actions: GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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