GW7647

SIGMA/G6793 - ≥98% (HPLC)

Synonym: 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid

CAS Number: 265129-71-3
Empirical Formula (Hill Notation): C₂₉H₄₆N₂O₃S
Molecular Weight: 502.75
MDL Number: MFCD06798379
Linear Formula: C₂₉H₄₆N₂O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G6793-5MG	5 mg	$267.00 1/EA	Add To Favorites
45-G6793-25MG	25 mg	$1050.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
InChI	1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
InChI key	PKNYXWMTHFMHKD-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O
solubility	DMSO: soluble 16 mg/mL
	H₂O: insoluble

Application:	GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand: • in defatting medium to treat primary human hepatocytes • to test its effect on the glycolytic function in cardiomyocytes • to test its effect on infant mouse heart • in breast cancer MDA-MB-231 cells to activate PPARs
Biochem/physiol Actions:	GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.
Biochem/physiol Actions:	Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.
Features and Benefits:	This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Legal Information:	Sold for research purposes only under agreement from GlaxoSmithKline
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
UNSPSC	12352200

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