Proguanil hydrochloride
SIGMA/G7048 - ≥95% (HPLC)
Synonym: Chlorguanide; N1-(4-Chlorophenyl)-N5-isopropylbiguanide
CAS Number: 637-32-1
Empirical Formula (Hill Notation): C11H16ClN5·HCl
Molecular Weight: 290.19
EC Number: 211-283-7
MDL Number: MFCD01732193
Linear Formula: C11H16ClN5·HCl
Product Type: Chemical
| assay | ≥95% (HPLC) |
| form | solid |
| InChI | 1S/C11H16ClN5.ClH/c1-7(2) |
| InChI key | SARMGXPVOFNNNG-UHFFFAOYSA |
| originator | AstraZeneca |
| Quality Level | 100  |
| SMILES string | Cl.CC(C)NC(=N)NC(=N)Nc1cc |
| solubility | acetonitrile: water: ~1 mg/mL (60/40) |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. |
| Biochem/physiol Actions: | Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains. |
| Biochem/physiol Actions: | Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor |
| Features and Benefits: | This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51101906 |