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GSK3787

SIGMA/G7423 - ≥98% (HPLC), white to off-white, powder

Synonym: 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide

CAS Number: 188591-46-0
Empirical Formula (Hill Notation): C15H12ClF3N2O3S
Molecular Weight: 392.78
MDL Number: MFCD00099612
Linear Formula: C15H12ClF3N2O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G7423-5MG 5 mg
 $157.00
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assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22)
InChI key JFUIMTGOQCQTPF-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string O=S(C1=CC=C(C=N1)C(F)(F)F)(CCNC(C2=CC=C(Cl)C=C2)=O)=O
solubility DMSO: ≥10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: GSK3787 has been used to inhibit the role of peroxisome proliferator-activated receptor-delta (PPARδ), during the pre-implantation period of bovine embryonic development. It has also been used as a PPARδ-specific inhibitor in in vitro maturation (IVM) media to inhibit PPARδ.
Biochem/physiol Actions: GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5).
Biochem/physiol Actions: GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5). It acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells.
Biochem/physiol Actions: GSK3787 is known to exhibit pharmacokinetic properties.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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