Ganaxolone

SIGMA/G7795 - solid, ≥98% (HPLC)

Synonym: 3α-Hydroxy-3β-methyl-5α-pregnan-20-one; CCD 1042

CAS Number: 38398-32-2
Empirical Formula (Hill Notation): C₂₂H₃₆O₂
Molecular Weight: 332.52
MDL Number: MFCD00945298
Linear Formula: C₂₂H₃₆O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G7795-5MG	5 mg	$217.00 1/EA		Add To Favorites
45-G7795-25MG	25 mg	$746.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1
InChI key	PGTVWKLGGCQMBR-FLBATMFCSA-N
Quality Level	100
SMILES string	[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@](C)(O)C2
solubility	DMSO: ≥2 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Analysis Note:	The product is pure based on elemental analysis, NMR, MS, optical rotation and melting point.
Biochem/physiol Actions:	Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.
Biochem/physiol Actions:	Positive allosteric modulator of the GABA_A receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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