Glucagon-Like Peptide 2 -Arg human trifluoroacetate salt
SIGMA/G8166 - >90% (HPLC), solid
Synonym: GLP-2-Arg; Preproglucagon 126-159
CAS Number: 99120-49-7
Empirical Formula (Hill Notation): C171H266N48O56S
Molecular Weight: 3922.29
MDL Number: MFCD02258932
Linear Formula: C171H266N48O56S
Product Type: Chemical
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| assay | >90% (HPLC) |
| form | solid |
| Quality Level | 200  |
| storage temp. | −20°C |
| UniProt accession no. | P01275  |
| Amino Acid Sequence: | His-Ala-Asp-Gly-Ser-Phe-S |
| Application: | Glucagon-Like Peptide 2 (GLP-2) -Arg human trifluoroacetate salt has been used for injection in chickens to determine the effects of GLP-2 on the weight and morphology of small intestines. |
| Biochem/physiol Actions: | Glucagon-like peptide 2 (GLP-2) influences the functionality of gastrointestinal tract by participating in the feedback loop to the brain for the control of food intake. It also controls digestion and absorption, and has tropic effects post chemotherapy injury or surgical resection. This peptide is also responsible for epithelial cell proliferation of the small bowel. Studies in rats show that this peptide enhances the effects of the ileal-brake hormones, GLP-1 and peptide YY. It also negatively regulates gastrointestinal motility and secretion. Thus, it has potential as a therapeutic agent in short-bowel syndrome. |
| Biochem/physiol Actions: | Glucagon-like peptide 2 is a neuropeptide that inhibits food intake when injected into the lateral ventricles of the brain and may mediate satiety. It is also a growth factor that stimulates proliferation and blocks apoptosis of intestinal epithelial cells. |
| Biochem/physiol Actions: | Neuropeptide that inhibits food intake when injected into the lateral ventricles of the brain and may mediate satiety; also a growth factor that stimulates proliferation and blocks apoptosis of intestinal epithelial cells. |
| General description: | Glucagon-like peptide 2 (GLP-2) is a member of the pro-glucagon gene family which is released in small and large intestinal circulation by enteroendocrine L cells. This peptide is composed of 33 amino acids. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |