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GW833972A

SIGMA/G8173 - ≥98% (HPLC), powder

Synonym: 2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride

CAS Number: 1092502-33-4
Empirical Formula (Hill Notation): C18H13ClF3N5O · HCl
Molecular Weight: 444.24
MDL Number: MFCD18452844
Linear Formula: C18H13ClF3N5O · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G8173-5MG 5 mg
 $214.00
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assay ≥98% (HPLC)
color off-white to light brown
drug control regulated under CDSA - not available from Sigma-Aldrich Canada
form powder
InChI 1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H
InChI key UBHSVFAUAKIVKL-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3
solubility DMSO: ≥20 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent.
Biochem/physiol Actions: GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1.
Biochem/physiol Actions: GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.
Biochem/physiol Actions: GW833972A is a CB2 receptor agonist with 1000-fold selectivity relative to CB1.
Biochem/physiol Actions: The compound was used to determine the role of CB2 in airway sensory nerve function.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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