L-Glutamic acid
SIGMA/G8415 - from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
Synonym: (S)-2-Aminopentanedioic acid; Glu
CAS Number: 56-86-0
Empirical Formula (Hill Notation): C5H9NO4
Molecular Weight: 147.13
EC Number: 200-293-7
MDL Number: MFCD00002634
Linear Formula: HO2CCH2CH2CH(NH2)CO2H
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G8415-100G
This image depicts SKU: G8415-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G8415-1KG
This image depicts SKU: G8415-1KG
| agency | meets EP testing specifications |
| anion traces | chloride (Cl-): ≤200 ppm |
| sulfate (SO42-): ≤200 ppm | |
| application(s) | pharmaceutical (small molecule) |
| assay | 98.5-100.5% |
| biological source | non-animal source |
| cation traces | As: ≤1 ppm, passes test |
| Fe: ≤10 ppm, passes test | |
| NH4+: ≤200 ppm, passes test | |
| color | white |
| density | 1.54 g/cm3 at 20 °C |
| form | powder |
| impurities | endotoxin, tested |
| InChI | 1S/C5H9NO4/c6-3(5(9)10)1- |
| InChI key | WHUUTDBJXJRKMK-VKHMYHEASA |
| mp | 205 °C (dec.) (lit.) |
| Quality Level | 300  |
| SMILES string | N[C@@H](CCC(O)=O)C(O)=O |
| solubility | 1 M HCl: 100 mg/mL |
| technique(s) | cell culture | mammalian: suitable |
| Application: | L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line. |
| Biochem/physiol Actions: | An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). |
| Biochem/physiol Actions: | Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase. Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis. |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 100 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | 98.5-100.5% |
| mp | 205 °C (dec.) (lit.) |
| Density | 1.54 g/cm3 at 20 °C |
| UNSPSC | 12352209 |