Guanosine 5′-[γ-thio]triphosphate tetralithium salt

SIGMA/G8634 - ≥90% (contains < 10% GDP, HPLC), powder

Synonym: GTPγS tetralithium salt; GTP-γ-S-Li₄; Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

CAS Number: 94825-44-2
Empirical Formula (Hill Notation): C₁₀H₁₂Li₄N₅O₁₃P₃S
Molecular Weight: 562.98
EC Number: 305-606-1
MDL Number: MFCD00135151
Linear Formula: C₁₀H₁₂Li₄N₅O₁₃P₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G8634-1MG	1 mg	$94.80 1/EA	Add To Favorites
45-G8634-5MG	5 mg	$311.00 1/EA	Add To Favorites
45-G8634-10MG	10 mg	$441.00 1/EA	Add To Favorites
45-G8634-25MG	25 mg	$1120.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G8634-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (contains < 10% GDP, HPLC)
color	white to off-white
form	powder
InChI	1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
InChI key	AMQXJFWJOAWCPV-ZVQJTLEUSA-J
Quality Level	200
shipped in	dry ice
SMILES string	[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1
solubility	H₂O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)
storage temp.	−20°C

Application:	Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used: • as a component of lysis buffer • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state • to couple with G- protein α, to study its effect on kinase activity
Biochem/physiol Actions:	GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.
Biochem/physiol Actions:	Non-hydrolyzable GTP analog, a G-protein activator.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	1, 5, 10, 25 mg in glass bottle

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (contains < 10% GDP, HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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