Guanosine 5′-triphosphate sodium salt hydrate

SIGMA/G8877 - ≥95% (HPLC), powder

Synonym: GTP

CAS Number: 36051-31-7
Empirical Formula (Hill Notation): C₁₀H₁₆N₅O₁₄P₃ · xNa⁺
Molecular Weight: 523.18 (free acid basis)
EC Number: 252-847-2
MDL Number: MFCD00077781
Linear Formula: C₁₀H₁₆N₅O₁₄P₃ · xNa⁺
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G8877-10MG	10 mg	$41.70 1/EA	Add To Favorites
45-G8877-25MG	25 mg	$72.30 1/EA	Add To Favorites
45-G8877-100MG	100 mg	$170.00 1/EA	Add To Favorites
45-G8877-250MG	250 mg	$285.00 1/EA	Add To Favorites
45-G8877-1G	1 g	$806.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G8877-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white
form	powder
InChI	1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
InChI key	KZRMTEVIDYXWQW-CYCLDIHTSA-K
Quality Level	200
shipped in	dry ice
SMILES string	[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
solubility	H₂O: 50 mg/mL
storage temp.	−20°C

Application:	Guanosine 5′-triphosphate sodium salt hydrate has been used: • in the preparation of horseradish peroxidase (HRP)-modified platination reagents • in whole cell, voltage-clamp recordings • in in vitro inhibition of transglutaminase (tTG)
Biochem/physiol Actions:	GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
Biochem/physiol Actions:	Guanosine-5′-triphosphate is a purine nucleotide that acts as a substrate for the synthesis of RNA during the transcription. GTP is a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. Activates the signal transducing G proteins involved in proliferation, differentiation, and activation of several intracellular kinase cascades.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	1 g in poly bottle
Packaging:	10, 25, 100, 250 mg in poly bottle
Preparation Note:	Prepared by enzymatic phosphorylation of 5′-GMP.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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