Gastrin I human

SIGMA/G9020 - ≥95% (HPLC), powder

Synonym: Gastrin I, heptadecapeptide; HG-17; Little gastrin I, human; [18-Pyroglutamic acid]big gastrin I-(18-34)-peptide amide, human; [pGlu¹⁸]-Big gastrin I fragment 18-34 amide

CAS Number: 10047-33-3
Empirical Formula (Hill Notation): C₉₇H₁₂₄N₂₀O₃₁S
Molecular Weight: 2098.20
EC Number: 233-157-0
MDL Number: MFCD00076500
Linear Formula: C₉₇H₁₂₄N₂₀O₃₁S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G9020-250UG	250 µg	$257.00 1/EA	Add To Favorites
45-G9020-.5MG	0.5 mg	$443.00 1/EA	Add To Favorites
45-G9020-1MG	1 mg	$852.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
biological source	human
concentration	≤100%
form	powder
InChI	1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1
InChI key	GKDWRERMBNGKCZ-RNXBIMIWSA-N
mol wt	2098.20
Quality Level	200
SMILES string	CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H]6CCCN6C(=O)CNC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc8ccccc8)C(N)=O
solubility	water: 1.00-1.04 mg/mL, clear, colorless
storage condition	(Keep container tightly closed in a dry and well-ventilated place)
storage temp.	−20°C
technique(s)	protein expression: suitable
UniProt accession no.	P01350

Amino Acid Sequence:	Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Application:	Gastrin I human has been used:• to treat AGS stably transfected with gastrin receptor/cholecystokinin receptor 2 (CCK2R) (AGS-GR) cells to study the expression and secretion of clusterin (CLU) in human gastric cancer cells • as a component of growth medium for culturing mouse normal esophageal epithelial organoid (mNEEO) • as a supplement in basal culture media to use for organoid-like cultures • as a molecular weight marker to calibrate superdex^® 30 columns.
Biochem/physiol Actions:	Gastrin plays a major role in parietal cell function, gastric epithelial cell multiplication, and differentiation. It acts as a modulator in maintaining and organizing gastric mucosa. It is produced in the stomach and stimulates gastric acid secretion. Gastrin is an important growth factor for the gastrointestinal tract. Gastrin binds with high affinity to the cholecystokinin B receptor (CCKBR) that belongs to the family of G-protein coupled receptors. It induces islet differentiation in the pancreas.
General description:	Research area: Cell Signaling The GAST gene is mapped to human chromosome 17q21. Gastrin is a linear peptide. It is a gastrointestinal hormone, produced by G cells in the stomach.
Legal Information:	Superdex is a registered trademark of Cytiva
Other Notes:	Lyophilized from 0.1% TFA in H2O

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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