GNF-2

SIGMA/G9420 - ≥98% (HPLC), solid

Synonym: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

CAS Number: 778270-11-4
Empirical Formula (Hill Notation): C₁₈H₁₃F₃N₄O₂
Molecular Weight: 374.32
MDL Number: MFCD09265253
Linear Formula: C₁₈H₁₃F₃N₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G9420-5MG	5 mg	$267.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white
form	solid
InChI	1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChI key	WEVYNIUIFUYDGI-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2
solubility	DMSO: ≥5 mg/mL
	H₂O: <2 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	GNF-2 belongs to a new class of Bcr-abl inhibitors. GNF-2 appears to bind to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. It inhibits Bcr-abl phosphorylation with an IC₅₀ of 267 nM, but does not inhibit a panel of 63 other kinases, including native c-Abl, and shows complete lack of toxicity towards cells not expressing Bcr-Abl. GNF-2 shows great potential for a new class of inhibitor to study Bcr-abl activity and to treat resistant Chronic myelogenous leukemia (CML), which is caused the Bcr-Abl oncoprotein.
Biochem/physiol Actions:	GNF-2 is a Bcr-abl kinase inhibitor and antiangiogenic agent with exclusive antiproliferative activity toward Bcr-abl-transformed cells.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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