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Glabridin

SIGMA/G9548 - ≥98% (HPLC), powder

Synonym: 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol; Glabridin; (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol

CAS Number: 59870-68-7
Empirical Formula (Hill Notation): C20H20O4
Molecular Weight: 324.37
MDL Number: MFCD03427694
Linear Formula: C20H20O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G9548-5MG 5 mg
 $143.00
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45-G9548-25MG 25 mg
 $568.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChI key LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Quality Level 100 
SMILES string CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c4ccc(O)cc4O
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. room temp
Application: Glabridin has been used:
• to analyze its transthyretin (TTR)-stabilizing effect in plasma of healthy volunteers
• as a standard in proton nuclear magnetic resonance (1H NMR) to study the interaction between glabridin and human serum albumin using multi-spectroscopic and molecular docking techniques
• to study its effect on nucleotide-binding oligomerization domain-like receptor pyrin-domain-containing protein 3 (NLRP3) inflammasome activation
Biochem/physiol Actions: Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. Glabridin has been reported to possess various biological activities including strong antioxidant activity, antioxidant against LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity and antinephritic and radical scavenging activities. Also it appears to inhibit serotonin re-uptake, melanogenesis, inflammation and cytochrome P450 3A4, 2B6, and 2C9.
Biochem/physiol Actions: Glabridin is a main component of glavonoid, also known as licorice-derived flavonoid oil, which is a natural supplement used in traditional medicine and herbal medicine.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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