Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit
SIGMA/G9665 - affinity isolated antibody, buffered aqueous glycerol solution
MDL Number: MFCD01633637
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | mouse, feline, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (frozen sections): 1:500 |
| western blot: 1:1,000 | |
| UniProt accession no. | P23385  |
| Application: | Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit is suitable for use as a primary antibody at a working dilution of 1:1500 using extracts from mouse brain It is suitable for immunohistochemistry at a working dilution of 1:500 and for immunoblotting at a working dilution of 1:1000. |
| Biochem/physiol Actions: | Glutamate Receptor 1 is a G-protein coupled receptor for glutamate. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are important mediators of excitatory amino acid neurotransmission. The α isomer of this receptor is a disulfide-linked homodimer and its activity is mediated by a G-protein-coupled phosphatidylinositol-calc |
| Biochem/physiol Actions: | This antibody does not react with other splice variants or mGluR5. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors. |
| Immunogen: | synthetic peptide corresponding to the sequence of amino acids 1116-1130 of rat metabotropic glutamate receptor 1A (mGluR1a). |
| Physical form: | 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |