GW9508

SIGMA/G9797 - ≥98% (HPLC)

Synonym: 4-(3-Phenoxybenzylamino)phenylpropionic acid

CAS Number: 885101-89-3
Empirical Formula (Hill Notation): C₂₂H₂₁NO₃
Molecular Weight: 347.41
MDL Number: MFCD09753282
Linear Formula: C₂₂H₂₁NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G9797-5MG	5 mg	$178.00 1/EA		Add To Favorites
45-G9797-25MG	25 mg	$692.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
InChI key	DGENZVKCTGIDRZ-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1
solubility	DMSO: >20 mg/mL
storage temp.	2-8°C

Application:	GW9508 has been used in: • cell proliferation assay in pancreatic cancer cells • in motility assay in melanoma cells • cell invasion assay in colon cancer cells
Application:	GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.
Biochem/physiol Actions:	GW9508 is a selective FFA1/GPR40 agonist.
Biochem/physiol Actions:	GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca²⁺ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn,N
Risk Statements	22-37/38-41-50/53
Safety Statements	26-39-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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