Gliotoxin from Gliocladium fimbriatum

SIGMA/G9893

Synonym: Aspergillin

CAS Number: 67-99-2
Empirical Formula (Hill Notation): C₁₃H₁₄N₂O₄S₂
Molecular Weight: 326.39
MDL Number: MFCD00058534
Linear Formula: C₁₃H₁₄N₂O₄S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G9893-5MG	5 mg	$281.00 1/EA		Add To Favorites
45-G9893-25MG	25 mg	$883.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	viruses
InChI	1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChI key	FIVPIPIDMRVLAY-RBJBARPLSA-N
mode of action	DNA synthesis \| interferes
	enzyme \| inhibits
Quality Level	200
SMILES string	CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
storage temp.	2-8°C

Application:	Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.
Application:	Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro.
Biochem/physiol Actions:	Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.
General description:	Chemical structure: epipolythiodioxopiperazine
General description:	Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.
Packaging:	5, 25 mg in serum bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	36/37/39-45
RIDADR	UN 3462 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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