MabSelect™ Xtra
SIGMA/GE17-5269-02 - Cytiva 17-5269-02, pack of 200 mL
Synonym: affinity resin; chromatography resin; gel; mAb purification resin; matrix; protein A resin
Product Type: Chemical
| avg. part. size | 75 (d₅₀v is the median particle size of the cumulative volume distribution) |
| capacity | ≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time) |
| cleaning in place | 2-12 |
| ligand | recombinant protein A (E. coli) |
| manufacturer/tradename | Cytiva 17-5269-02 |
| matrix | highly cross-linked agarose |
| packaging | pack of 200 mL |
| storage condition | (20% Ehtanol) |
| storage temp. | 2-8°C |
| suitability | suitable for bioprocess medium |
| working range | 3-10 |
| Analysis Note: | To view the Certificate of Analysis for this product, please visit www.cytiva.com   . |
| Application: | MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion Proteins. The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches. MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support. |
| Features and Benefits: | • Higher dynamic binding capacity than currently available Protein A chromatography media. • Improved process economics through reduced raw materials costs and/or reduced number of cycles • High purity capture due to high ligand selectivity and matrix hydrophilicity • Slightly lower pressure/fLow properties compared to MabSelect™ SuRe™ and MabSelect |
| General description: | Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm. |
| General description: | MabSelect™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks. |
| General description: | pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH. |
| Legal Information: | MabSelect is a trademark of Cytiva |
| Legal Information: | SuRe is a trademark of Cytiva |
| Preparation Note: | Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service. |
| Symbol |  GHS02 |
| Signal word | Warning |
| Hazard statements | H226 |
| Precautionary statements | P210 - P235 - P241 - P280 - P303 + P361 + P353 - P501 |
| RIDADR | NONH for all modes of transport |
| Storage Temp. | 2-8°C |
| UNSPSC | 41106500 |