HiTrap® Capto™ Adhere
SIGMA/GE28-4058-46 - Cytiva 28-4058-46, pack of 5 × 5 mL
Synonym: anion; chromatography cartridge; mAB resin; multimodal matrix; polishing media; prepacked column
Product Type: Chemical
| avg. part. size | 75 (d₅₀v is the median particle size of the cumulative volume distribution) |
| bed size | 16 mm × 25 mm |
| bed volume | 5 mL |
| cleaning | 2-14(pH interval where the medium can be subjected to, for cleaning- or sanitization-in-place.) |
| column I.D. | 16 mm |
| description | Ion Exchanger Type (value) |
| ligand | N-benzyl-N-methyl ethanolamine |
| manufacturer/tradename | Cytiva 28-4058-46 |
| matrix | highly cross-linked agarose |
| packaging | pack of 5 × 5 mL |
| parameter | <20 mL/min flow rate |
| 42 psi | |
| suitability | suitable for bioprocess medium |
| working range | 3-12(pH interval where the medium can be operated without significant change in function.) |
| Analysis Note: | To view the Certificate of Analysis for this product, please visit www.cytiva.com   . |
| Application: | Protein polishing using Capto™ Adhere Multimodal chromatography |
| Features and Benefits: | • High capacity and productivity in flowthrough mode. • Savings in time and operating costs with a two-step chromatographic process. • Wide operational window of pH and conductivity. • Prepacked HiTrap columns for easy screening and convenient process development. |
| General description: | HiTrap Capto adhere is prepacked with Capto adhere, a multimodal BioProcess ion exchange resin designed to remove contaminats in post-protein A purification. Capto adhere is a strong anion exchanger with multimodal functionality. The multimodal functionality gives a different selectivity compared to traditional anion exchangers. Capto adhere is designed for post-protein A purification of monoclonal antibodies. Removal of leached protein A, aggregates, host cell proteins, nucleic acids, and viruses from monoclonal antibodies is performed in flowthrough mode at which the antibodies pass directly through the column while the contaminants are adsorbed. For optimal performance of Capto adhere, screening/optimization of loading conditions are required. |
| Legal Information: | Capto is a trademark of Cytiva |
| Legal Information: | HiTrap is a registered trademark of Cytiva |
| Other Notes: | The pressure over the packed bed varies depending on a range of parameters such as the characteristics of the chromatography medium and the column tubing used. |
| Preparation Note: | Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service. |
| Preparation Note: | Store at 4 to 30 °C (20% Ethanol) |
| Symbol |  GHS02 |
| Signal word | Warning |
| Hazard statements | H226 |
| Precautionary statements | P210 - P235 - P241 - P280 - P303 + P361 + P353 - P501 |
| RIDADR | UN1170 - class 3 - PG 3 - Ethanol, solution |
| UNSPSC | 23151817 |