GST M5-5, Recombinant Human
SIGMA/GS59
Synonym: glutathione S-transferase mu 5
Product Type: Product-on-demand
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| assay | >95% (SDS-PAGE) |
| biological source | human |
| concentration | 3.2 mg/mL |
| form | frozen liquid |
| mol wt | 27.4 kDa |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| specific activity | 183.9 units/mg protein |
| storage temp. | −70°C |
| Biochem/physiol Actions: | Glutathione S-transferase mu 5 (GSTM5) is an enzyme that in humans is encoded by the GSTM5 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
| Biochem/physiol Actions: | The GSTM5 gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. |
| General description: | using spectrophotometric determination of 1-chloro-2,4-dinitrobenze |
| Preparation Note: | The enzyme should be used by the end-user customer within 1 year of receipt. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| activity | specific activity: 183.9 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |