GST A1-1, Recombinant Human
SIGMA/GS60
Synonym: GST-epsilon; GST2; GSTA1-1; GTH1; glutathione S-transferase alpha 1
Product Type: Product-on-demand
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| assay | >95% (SDS-PAGE) |
| biological source | human |
| concentration | 2.0 mg/mL |
| form | frozen liquid |
| mol wt | 23 kDa |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| specific activity | 21.04 units/mg protein |
| storage temp. | −70°C |
| Biochem/physiol Actions: | Glutathione S-transferase alpha 1 (GSTA1) is an enzyme that in humans is encoded by the GSTA1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
| Biochem/physiol Actions: | The GSTA1 gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. |
| General description: | using spectrophotometric determination of 1-chloro-2,4-dinitrobenze |
| Preparation Note: | The enzyme should be used by the end-user customer within 1 year of receipt. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| activity | specific activity: 21.04 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |