GST O1-1, Recombinant Human
SIGMA/GS75
Synonym: GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R; glutathione S-transferase omega 1
Product Type: Product-on-demand
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| assay | >95% (SDS-PAGE) |
| biological source | human |
| concentration | 1.98 mg/mL |
| form | frozen liquid |
| mol wt | 26 kDa |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| specific activity | 4.21 units/mg protein |
| storage temp. | −70°C |
| Biochem/physiol Actions: | Glutathione S-transferase omega 1 (GSTO1) is an enzyme that in humans is encoded by the GSTO1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
| Biochem/physiol Actions: | The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. |
| General description: | using spectrophotometric determination of 1-chloro-2,4-dinitrobenze |
| Preparation Note: | The enzyme should be used by the end-user customer within 1 year of receipt. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| activity | specific activity: 4.21 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |