GST T1-1, Recombinant Human
SIGMA/GS90
Synonym: glutathione S-transferase theta 1
Product Type: Product-on-demand
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| assay | 95% (SDS-PAGE) |
| biological source | human |
| concentration | 1.95 mg/mL |
| form | frozen liquid |
| mol wt | 25 kDa |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| specific activity | 8.8 units/mg protein |
| storage temp. | −70°C |
| Biochem/physiol Actions: | Glutathione S-transferase theta 1 (GSTT1) is an enzyme that in humans is encoded by the GSTT1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Mutation in the gene might lead to the development of lung, head and neck cancer. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
| General description: | as assayed by the spectrophotometric determination of NADPH oxidation coupled to the glutathione peroxidase activity of GST T1-1 on cumene hydroperoxide (1.5 mM) in the presence of reduced glutathione (1 mM) in 100 mM NaPO4 (pH 7.0) at room temperature. |
| General description: | Glutathione S-transferase theta 1 (GSTT1) and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants.GSTT1 is an enzyme that in humans is encoded by the GSTT1 gene. The GSTT1 gene contains five exons and four introns and spans 8092bp on genomic DNA. It is mapped to human chromosome 22q11.23. This gene codes for a 240 amino acids, which is mainly expressed in human liver. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, κ, μ, ω, π, σ, θ and ζ. |
| Preparation Note: | The enzyme should be used by the end-user customer within 1 year of receipt. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 95% (SDS-PAGE) |
| activity | specific activity: 8.8 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |