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7-Ethyl-10-hydroxycamptothecin

SIGMA/H0165 - ≥98% (HPLC), powder

Synonym: SN-38

CAS Number: 86639-52-3
Empirical Formula (Hill Notation): C22H20N2O5
Molecular Weight: 392.40
MDL Number: MFCD00871873
Linear Formula: C22H20N2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H0165-10MG 10 mg
 $226.00
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45-H0165-50MG 50 mg
 $787.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H0165-50MG

 

assay ≥98% (HPLC)
biological source Artemisia annua
form powder
InChI 1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChI key FJHBVJOVLFPMQE-QFIPXVFZSA-N
Quality Level 200 
SMILES string OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O
solubility DMSO: 1 mg/mL
storage temp. −20°C
Application: 7-Ethyl-10-hydroxycamptothecin has been used:
• to inhibit enterovirus 71 (EV71) (H) infection
• to screen the chemosensitivity of pancreatic adenocarcinoma cells
• as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters
Biochem/physiol Actions: Active metabolite of irinotecan. Inhibitor of topoisomerase I.
Biochem/physiol Actions: Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.
Packaging: 10 mg in glass bottle
Packaging: 50 mg in poly bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352204

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