Heparin Cofactor II from human plasma
SIGMA/H0417 - aqueous glycerol solution, ≥90% (SDS-PAGE)
Synonym: HCF2; HCII; SERPIND1
CAS Number: 81604-65-1
MDL Number: MFCD00285907
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| biological source | human plasma |
| form | aqueous glycerol solution |
| mol wt | ~66 kDa |
| NCBI accession no. | NP_000176   |
| Quality Level | 200 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy. |
| Biochem/physiol Actions: | Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| Other Notes: | HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin. |
| Physical form: | 50% aqueous glycerol solution (vol/vol) |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |