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6-Hydroxymelatonin

SIGMA/H0627

Synonym: 3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole

CAS Number: 2208-41-5
Empirical Formula (Hill Notation): C13H16N2O3
Molecular Weight: 248.28
MDL Number: MFCD00037971
Linear Formula: C13H16N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H0627-50MG 50 mg
 $862.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H0627-50MG

 

InChI 1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
InChI key OMYMRCXOJJZYKE-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
solubility alcohol: soluble
Application: 6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.
Biochem/physiol Actions: 6-Hydroxymelatonin (6-OHM) is an antioxidant with a free radical scavenging role. Like melatonin, it reduces the impact of UVB-induced oxidative stress in melanocytes. It also aids protection during iron (Fe2+)-induced neurotoxicity. 6-OHM effectively reduces lipid peroxidation and superoxide anion production induced by potassium cyanide (KCN).
General description: 6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.
Packaging: 50 mg in glass bottle
UNSPSC 41116107

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