Heregulin-β, EGF Domain human
SIGMA/H0786 - ≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution
Synonym: HRG-β
MDL Number: MFCD01867052
Product Type: Chemical
Epidermal
Growth Factor Receptor (EGFR) Pathway Research areas:
Cancer biology, Cell proliferation, Metabolism. Disease areas:
Breast, lung, stomach, gastrointestinal cancers, chronic kidney diseases,
glioblastomas.
| assay | ≥80% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | 185 kDa |
| packaging | pkg of 100 μg |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | Q02297  |
| Analysis Note: | Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor. |
| Analysis Note: | The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells. |
| Biochem/physiol Actions: | Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. |
| Biochem/physiol Actions: | Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation |
| General description: | Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin. |
| Physical form: | Solution in phosphate buffered saline containing 30% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |