Hydrocortisone

SIGMA/H0888 - BioReagent, suitable for cell culture

Synonym: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 17-Hydroxycorticosterone; 4-Pregnene-11β,17α,21-triol-3,20-dione; Cortisol; Kendall’s compound F; Reichstein’s substance M

CAS Number: 50-23-7
Empirical Formula (Hill Notation): C₂₁H₃₀O₅
Molecular Weight: 362.46
EC Number: 200-020-1
MDL Number: MFCD00011654
Linear Formula: C₂₁H₃₀O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-H0888-1G	1 g	$62.60 1/EA	Add To Favorites
45-H0888-5G	5 g	$238.00 1/EA	Add To Favorites
45-H0888-10G	10 g	$356.00 1/EA	Add To Favorites

FT-IR Spectra for 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H0888-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
biological source	soybean
form	powder
InChI	1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key	JYGXADMDTFJGBT-VWUMJDOOSA-N
mp	211-214 °C (lit.)
product line	BioReagent
Quality Level	200
shipped in	ambient
SMILES string	[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
solubility	chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow
storage temp.	room temp
technique(s)	cell culture \| mammalian: suitable

Application:	Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.
Biochem/physiol Actions:	Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.
Biochem/physiol Actions:	Primary glucocorticoid secreted by the adrenal cortex.
Biochem/physiol Actions:	Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.
Packaging:	1, 5, 10 g in poly bottle
Physical form:	powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Preparation Note:	To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360Df - H373
Precautionary statements	P202 - P260 - P280 - P308 + P313 - P405 - P501
Hazard Codes	Xn
Risk Statements	63
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
mp	211-214 °C (lit.)
Storage Temp.	room temp
UNSPSC	12352209

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