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Hydroxychloroquine sulfate

SIGMA/H0915 - ≥98% (HPLC), powder

Synonym: Hydroxychloroquine sulfate; 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate

CAS Number: 747-36-4
Empirical Formula (Hill Notation): C18H26ClN3O · H2SO4
Molecular Weight: 433.95
EC Number: 212-019-3
MDL Number: MFCD00078203
Linear Formula: C18H26ClN3O · H2SO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H0915-5MG 5 mg
 $141.00
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45-H0915-25MG 25 mg
 $589.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H0915-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H0915-5MG

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI key JCBIVZZPXRZKTI-UHFFFAOYSA-N
Quality Level 100 
SMILES string OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
solubility H2O: >20 mg/mL
storage condition protect from light
Application: Hydroxychloroquine sulfate has been used:
• as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
• to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
• to inhibit lysosome fusion with the autophagosome
Biochem/physiol Actions: Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.
Biochem/physiol Actions: Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor.
Biochem/physiol Actions: Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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