Hck human
SIGMA/H1038 - recombinant, expressed in E. coli BL21, vial of ≥200 units
MDL Number: MFCD03792313
Product Type: Chemical
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| form | solution |
| packaging | vial of ≥200 units |
| Quality Level | 200  |
| recombinant | expressed in E. coli BL21 |
| relevant disease(s) | cancer (leukemia) |
| shipped in | dry ice |
| specific activity | 1-2 unit/μg protein |
| storage temp. | −70°C |
| Application: | Hck is a protein-tyrosine kinase that is expressed in hemopoietic cells. It is used in leukemia research . |
| Biochem/physiol Actions: | Hck is a member of the Src tyrosine kinase family. Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia . |
| Other Notes: | One unit will phosphorylate 1.0 picomole of Tyr15 of the peptide substrate pcdc2 6-20 per minute at 30 °C at pH 7.4. |
| Physical form: | Supplied as a solution in 50 mM Tris HCl, pH 7.4, 1 mM EDTA and 1 mM DTT |
| WGK Germany | 1 |
| activity | specific activity: 1-2 unit/μg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |