Haloperidol

SIGMA/H1512 - powder

Synonym: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone; 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone; 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

CAS Number: 52-86-8
Empirical Formula (Hill Notation): C₂₁H₂₃ClFNO₂
Molecular Weight: 375.86
EC Number: 200-155-6
MDL Number: MFCD00051423
Linear Formula: C₂₁H₂₃ClFNO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-H1512-5G	5 g	$141.00 1/EA	Add To Favorites
45-H1512-10G	10 g	$271.00 1/EA	Add To Favorites
45-H1512-25G	25 g	$552.00 1/EA	Add To Favorites

FT-NMR Spectra for 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H1512-25G

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	powder
InChI	1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
InChI key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
originator	Johnson & Johnson
Quality Level	200
SMILES string	OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3
solubility	0.1 M HCl: 3 mg/mL
	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
	DMSO: soluble
	ethanol: soluble
	H₂O: insoluble

Application:	Haloperidol has been used: • in ethanol to serves as an inhibitor of Erg2p • to address the mechanism of haloperidol in ferroptosis using hepatocellular carcinoma cells: Hep G2 and Huh-7 cell lines • in receptor internalization assay • as an antipsychotic drug in Dulbecco′s Modified Eagle medium
Biochem/physiol Actions:	Haloperidol is a butyrophenone antipsychotic. It is also classified as a neuroleptic (powerful tranquilizer). Haloperidol acts as a D2, D3, and D4 dopamine receptor antagonist and thus causes Parkinson′s disorder. It also has a negative effect on the central nervous system.
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	5, 10, 25 g in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H315 - H317 - H319 - H335 - H361
Precautionary statements	P201 - P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	60-61-25-36/37/38-43
Safety Statements	53-26-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352200

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