Synonym: Hexamethonium dichloride; N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride; N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dichloride
CAS Number: 60-25-3
Empirical Formula (Hill Notation): C12H30Cl2N2
Molecular Weight: 273.29
EC Number: 200-465-1
MDL Number: MFCD00031563
Linear Formula: (CH3)3N(Cl)(CH2)6N(Cl)(CH3)3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H2138-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H2138-25G
color |
white |
form |
solid (hygroscopic) |
InChI |
1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2 |
InChI key |
PYIHTIJNCRKDBV-UHFFFAOYSA-L |
SMILES string |
[Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C |
solubility |
ethanol: soluble |
|
H2O: soluble |
Application: |
Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons. |
Biochem/physiol Actions: |
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR. |
General description: |
Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction. |
Packaging: |
5, 25 g in poly bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |