Anti-HAP40 antibody produced in rabbit
SIGMA/H2539 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-
MDL Number: MFCD03791872
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~40 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1,000 using mouse brain |
| UniProt accession no. | Q00558  |
| Application: | Co-immunoprecipitates Huntingtin protein. |
| Biochem/physiol Actions: | Huntingtin-associated protein 40 (HAP40) acts as an effector of Ras-related protein 5 (Rab5) It interacts with huntingtin (HTT). HAP40 may participate in the abnormal nuclear localization of mutant huntingtin identified in Huntington′s disease degenerating neurons. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | HAP40 is a 40 kDa Huntingtin-associated protein. It islikely to contribute to the function of normal huntintinand is a candidate for involvement in the aberrantnuclear localization of mutant huntingtin found indegenerating neurons in Huntington’s |
| General description: | Three sequence-identical paralogs of the factor VIII intronic transcript A (F8A) gene codes for huntingtin-associated protein 40 (HAP40) in humans. In amniotes, HAP40 is coded by a single-exon gene (SEG). The F8A or coagulation factor VIII-associated 1 (F8A1) gene is located on human chromosome Xq28. |
| Immunogen: | peptide corresponding to the mouse HAP40 protein (amino acids 314-325). |
| Physical form: | Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
| WGK Germany | 3 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |