Hemoglobin from bovine blood
SIGMA/H2625 - suitable for protease substrate, substrate powder
Synonym: Bovine hemoglobin; Hb; Methemoglobin
CAS Number: 9008-02-0
MDL Number: MFCD00131282
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H2625-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H2625-25G
| biological source | bovine blood |
| form | substrate powder |
| mol wt | Mr ~64500 |
| Quality Level | 300  |
| solubility | H2O: soluble 20 mg/mL |
| storage temp. | 2-8°C |
| suitability | suitable for protease substrate |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P01966  |
| P02070 |
|
| P02081 |
|
| P06642 |
|
| P06643 |
| Application: | Hemoglobin from bovine blood has been used as a substrate in cathepsin D activity assay. It has also been used to measure the activity of acid proteases (pepsin-like) in the stomach extract. |
| Application: | The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials. |
| Biochem/physiol Actions: | Bovine hemoglobin is used in the production of hemoglobin-vesicles (HbV). It has high thermal stability and high oxygen affinity when compared to human hemoglobin. Bovine hemoglobin interacts with synthetic and azo dyes. Polymerized forms of bovine hemoglobin are used to treat autoimmune hemolytic anemia. |
| Biochem/physiol Actions: | Oxygen transporter, NO scavenger |
| Biochem/physiol Actions: | Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues. |
| Disclaimer: | Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin. |
| General description: | Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is a globular protein with α and β chains with every 141 and 146 amino acids respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme. |
| Packaging: | 1 kg in poly drum |
| Packaging: | 25, 100 g in glass bottle |
| Preparation Note: | Prepared from washed, lysed and dialyzed erythrocytes. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |