HCK (230-497), active, GST tagged human
SIGMA/H2915 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: JTK9
Product Type: Chemical
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| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~57 kDa |
| product line | PRECISIO® Kinase |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected Sf9 cells |
| relevant disease(s) | cancer (leukemia) |
| shipped in | dry ice |
| specific activity | 156-212 nmol/min·mg |
| storage temp. | −70°C |
| UniProt accession no. | P08631  |
| Biochem/physiol Actions: | HCK (hematopoietic cell kinase) gene is mapped to human chromosome 20q11-q12. This region on the chromosome urdergoes interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders, thereby suggesting HCK participation in the pathogenesis of these conditions. |
| General description: | HCK (hematopoietic cell kinase), a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells. It is especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 156-212 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |