Hydrocortisone

SIGMA/H3160 - meets USP testing specifications

Synonym: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 17-Hydroxycorticosterone; 4-Pregnene-11β,17α,21-triol-3,20-dione; Cortisol; Kendall’s compound F; Reichstein’s substance M

CAS Number: 50-23-7
Empirical Formula (Hill Notation): C₂₁H₃₀O₅
Molecular Weight: 362.46
EC Number: 200-020-1
MDL Number: MFCD00011654
Linear Formula: C₂₁H₃₀O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-H3160-5G	5 g	$159.00 1/EA	Add To Favorites
45-H3160-10G	10 g	$279.00 1/EA	Add To Favorites
45-H3160-25G	25 g	$550.00 1/EA	Add To Favorites

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This image depicts SKU: H3160-25G

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
application(s)	pharmaceutical (small molecule)
assay	97.0-102.0% dry basis
biological source	plant (wild yam)
form	powder
InChI	1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key	JYGXADMDTFJGBT-VWUMJDOOSA-N
mp	211-214 °C (lit.)
potency	0.004-0.005 μg/mL
Quality Level	300
SMILES string	[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
solubility	water: soluble 0.28 g/L at 25 °C

Application:	Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024 ). Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024 ).
Biochem/physiol Actions:	Primary glucocorticoid secreted by the adrenal cortex.
Biochem/physiol Actions:	Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.
Packaging:	5, 10, 25 g in poly bottle
Physical form:	powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Symbol	GHS08
Signal word	Danger
Hazard statements	H360Df - H373
Precautionary statements	P202 - P260 - P280 - P308 + P313 - P405 - P501
Hazard Codes	Xn
Risk Statements	63
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	97.0-102.0% dry basis
mp	211-214 °C (lit.)
UNSPSC	51111800

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