Hydroxyflutamide
SIGMA/H4166 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 52806-53-8
Empirical Formula (Hill Notation): C11H11F3N2O4
Molecular Weight: 292.21
MDL Number: MFCD00563126
Linear Formula: C11H11F3N2O4
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts H4166-25MG
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C11H11F3N2O4/c1-10(2,1 |
| InChI key | YPQLFJODEKMJEF-UHFFFAOYSA |
| originator | Schering Plough |
| Quality Level | 100  |
| SMILES string | CC(C)(O)C(=O)Nc1ccc(c(c1) |
| solubility | DMSO: >10 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | Hydroxyflutamide has been used: • as an androgen receptor antagonist to study its effects on cardiomyocyte hypertrophy induced by dihydrtestosterone (DHT) in primary neonatal rat ventricular cardiomyocyte and rat cardio myoblast (H9c2) cells. • as an androgen receptor antagonist for the treatment of MDA-kb2 cells to check its effect on luciferase expression. • as an antagonist control in transcriptional activation assay. |
| Biochem/physiol Actions: | Hydroxflutamide is an AR (androgen receptor) antagonist. |
| Biochem/physiol Actions: | Hydroxflutamide is an AR antagonist. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors. Hydroxyflutamide is an androgen antagonist with publications going back to 1981. It is one of a few gold standard AR antagonists; activities of new antagonists are measured against hydroxyflutamide. |
| Biochem/physiol Actions: | Hydroxyflutamide plays a role in preventing the binding of 5α-dihydrotestosterone (DHT) and testosterone to the androgen receptors. |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Schering Plough . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 51111800 |