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6-Hydroxydopamine hydrochloride

SIGMA/H4381 - ≥97% (titration), powder

Synonym: 2,4,5-Trihydroxyphenethylamine hydrochloride; 2,5-Dihydroxytyramine hydrochloride; 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride; 6-OHDA

CAS Number: 28094-15-7
Empirical Formula (Hill Notation): C8H11NO3 · HCl
Molecular Weight: 205.64
EC Number: 248-837-2
MDL Number: MFCD00012895
Linear Formula: (HO)3C6H2CH2CH2NH2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H4381-100MG 100 mg
 $148.00
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45-H4381-500MG 500 mg
 $570.00
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45-H4381-1G 1 g
 $874.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H4381-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H4381-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H4381-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H4381-500MG

 

assay ≥97% (titration)
color off-white to brown
form powder
InChI 1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChI key QLMRJHFAGVFUAC-UHFFFAOYSA-N
mp 232-233 °C (dec.) (lit.)
Quality Level 100 
SMILES string Cl.NCCc1cc(O)c(O)cc1O
solubility H2O: >50 mg/mL, clear, yellow to brown
storage temp. room temp
Application: 6-hydroxydopamine hydrochloride has been used:
• to induce Parkinson′s disease (PD) in rats
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus
Biochem/physiol Actions: Neurotoxin that destroys catecholaminergic terminals.
Disclaimer: Hygroscopic
General description: 6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Packaging: 1 g in glass bottle
Packaging: 100, 500 mg in glass insert
Preparation Note: Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.
Preparation Note: Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.
Purity ≥97% (titration)
mp 232-233 °C (dec.) (lit.)
Storage Temp. room temp
UNSPSC 12352116

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