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Hydroxyfasudil hydrochloride hydrate

SIGMA/H4413 - ≥98% (HPLC), solid

Synonym: 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate

CAS Number: 155558-32-0 (anhydrous)
Empirical Formula (Hill Notation): C14H17N3O3S · HCl · xH2O
Molecular Weight: 343.83 (anhydrous basis)
MDL Number: MFCD06411567
Linear Formula: C14H17N3O3S · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H4413-5MG 5 mg
 $315.00
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45-H4413-25MG 25 mg
 $1190.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
composition The two peaks show the equilibrim between the two tautomers
form solid
InChI 1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChI key XWWFOUVDVJGNNG-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3
solubility H2O: >5 mg/mL
storage temp. 2-8°C
Application: Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.
Biochem/physiol Actions: Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.
Biochem/physiol Actions: Rho-kinase inhibitor.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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