HPI-4
SIGMA/H4541 - ≥98% (HPLC)
Synonym: 2,4-
CAS Number: 302803-72-1
Empirical Formula (Hill Notation): C17H9Cl2N3O2
Molecular Weight: 358.18
MDL Number: MFCD01911757
Linear Formula: C17H9Cl2N3O2
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts H4541-5MG
| assay | ≥98% (HPLC) |
| color | off-white, off-white to orange |
| form | powder |
| InChI | 1S/C17H9Cl2N3O2/c18-9-5-6 |
| InChI key | SESYPWCSIZUIAS-FOWTUZBSSA |
| Quality Level | 100  |
| SMILES string | Clc1ccc(c(Cl)c1)C(=O)C(C |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | Hedgehog pathway inhibitor (HP1-4) has been used for the inhibition of dynein ATPase in Leishmania. |
| Biochem/physiol Actions: | HPI-4 is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. |
| Biochem/physiol Actions: | HPI-4 is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. A key signaling molecule in HH pathway, Smoothened (Smo), has been the target of pharmacological intervention, which has resulted in multiple Smo antagonists including Cyclopamine. However, the oncogenic form of Smo is resistant to Cyclopamine, so the identification of inhibitors of downstream effectors, such as the transcription factors Gli1 and Gli2, is important. Four small molecules were identified to inhibit HH downstream of Smo, HPI-1, HPI-2, HPI-3, and HPI-4. HPI-4 blocked HH pathway activation by SAG, decreased Smo ciliary accumulation, decreased HH activity in a consitutively active HH cell line, and decreased Gli1 and Gli2, processing, and stability. HPI-4 inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling. Cilia in HPI-4-treated cells were either truncated or absent. The mechanism of action of HPI-4 is hypothesized to be directly through perturbation of ciliogenesis, leading to disruption of Gli1/Gli2 activity, which is distinctly different from that of Cyclopamine. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302 - H410 |
| Precautionary statements | P273 - P301 + P312 + P330 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |